Mary Muller was born in Illinois, the 2nd of 4 children. She graduated from Bloomfield Hills High School, Bloomfield Hills, Michigan, in a class of 24. Majoring in Studio Art, Muller graduated from Principia College in Elsah, Illinois.

After her marriage to Bill Muller of Des Moines, she began to pursue her art when their youngest of 5 children entered school. While studying with Dimitar Krustev in Des Moines she began teaching art to help augment the family income. This in turn became a career coupled with her painting. Drawing about 1000 portraits in art festivals and fairs, studying with Robert Brackman in Connecticut, teaching watercolor at the Des Moines Art Center, being represented by several art galleries, and travelling in Mexico and Europe on painting trips has given her a full life and wonderful experiences. Portrait commissions have become her major painting activity, while she struggles to work in as much landscape as possible. Teaching workshops in Iowa and other states, and entering local and national art competitions has allowed her to earn some awards and success in and beyond Iowa. Her volunteer efforts have centered around the teaching and development of art to inmates at the Mitchellville prison.